Pair Name	Dihydroartemisinin, Oxaliplatin
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	STAT3	hsa6774
	Up-regulation	Expression	MAPK8	hsa5599
	Up-regulation	Expression	MAPK14	hsa1432
	Down-regulation	Expression	PRDX2	hsa7001
	Up-regulation	Expression	ROS1	hsa6098
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Phosphorylation	EIF2S1	hsa1965
	Up-regulation	Expression	ATF4	hsa468
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	RKO	Colon carcinoma	Homo sapiens (Human)	CVCL_0504
In Vivo Model	The cells were subcutaneously injected into the flanks of nude mice at a concentration of 5×10⁶ cells in 100 μl of PBS/Matrigel mixture (1: 1).
Result	We demonstrated an improved therapeutic strategy for CRC patients by combining DHA and oxaliplatin treatments.