| Pair Name | Dihydroartemisinin, Oxaliplatin | ||
| Phytochemical Name | Dihydroartemisinin (PubChem CID: 3000518 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Dihydroartemisinin, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Phosphorylation | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | MAPK14 | hsa1432 | |
| Up-regulation | Expression | MAPK8 | hsa5599 | |
| Down-regulation | Expression | PRDX2 | hsa7001 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Down-regulation | Expression | STAT3 | hsa6774 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| In Vivo Model | The cells were subcutaneously injected into the flanks of nude mice at a concentration of 5×10⁶ cells in 100 μl of PBS/Matrigel mixture (1: 1). | |||
| Result | We demonstrated an improved therapeutic strategy for CRC patients by combining DHA and oxaliplatin treatments. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways. Phytomedicine. 2022 Apr;98:153932. doi: 10.1016/j.phymed.2022.153932. | Click |
